Computational STAT3 activity inference reveals Its roles at The pancreatic tumor microenvironmentNature #STAT3_Activity

Computational STAT3 activity inference reveals Its roles at The pancreatic tumor microenvironmentNature #STAT3_Activity

December 3, 2019 0 By NewsTakers

We thus applied indirect comparisons based on the correlation between TF expression levels and tumor purity across pancreatic cancer samples and compared this to pancreatic cancer cell lines, representing pure cancer cells.
Lastly, we observed that STAT3 target genes were more highly expressed in primary pancreatic cancer tissue, compared to pancreatic cancer cell lines (Fig.
STAT3 activities are prognostic in pancreatic cancer.
Forty-four pancreatic cancer cell lines were used to compare tumor gene expression to primary pancreatic cancer gene expression (Suppl Table 2 ).
Cancer 108 , 914–923 (2013).
Cancer 19 , 82–96 (2019).
Cancer Cell 19 , 441–455 (2011).
Cancer Cell 19 , 456–469 (2011).
Cancer 137 , 1035–1046 (2015).
Cancers 11 (2019).

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